| Function | Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas. Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. |
| Protein Name | C-Type Lectin Domain Family 6 Member AC-Type Lectin Superfamily Member 10Dendritic Cell-Associated C-Type Lectin 2Dc-Associated C-Type Lectin 2Dectin-2 |
| Database Links | Reactome: R-MMU-5621480Reactome: -MMU-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | C-Type Lectin Domain Family 6 Member A proteinC-Type Lectin Superfamily Member 10 proteinDendritic Cell-Associated C-Type Lectin 2 proteinDc-Associated C-Type Lectin 2 proteinDectin-2 proteinClec6a proteinClec4n proteinClecsf10 proteinDectin2 protein |
Information sourced from Uniprot.org
