| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
<0.1 EU/Mu g |
| Gene Symbol: |
Cd8a |
| Gene ID: |
12525 |
| Uniprot ID: |
CD8A_MOUSE |
| Immunogen: |
Recombinant Mouse CD8a Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys28-Tyr196) of mouse CD8 alpha (Accession #NP_001074579.1) fused with a hFc tag at the C-terminus. |
| Immunogen Sequence: |
KPQAPELRIFPKKMDAELGQ KVDLVCEVLGSVSQGCSWLF QNSSSKLPQPTFVVYMASSH NKITWDEKLNSSKLFSAMRD TNNKYVLTLNKFSKENEGYY FCSVISNSVMYFSSVVPVLQ KVNSTTTKPVLRTPSPVHPT GTSQPQRPEDCRPRGSVKGT GLDFACDIY |
| Function | Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. |
| Protein Name | T-Cell Surface Glycoprotein Cd8 Alpha ChainT-Cell Surface Glycoprotein Lyt-2Cd Antigen Cd8a |
| Database Links | Reactome: R-MMU-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCd8a Localizes To Lipid Rafts Only When Associated With Its Partner Cd8b |
| Alternative Protein Names | T-Cell Surface Glycoprotein Cd8 Alpha Chain proteinT-Cell Surface Glycoprotein Lyt-2 proteinCd Antigen Cd8a proteinCd8a proteinLyt-2 proteinLyt2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
