| Short Description : | Recombinant-Active-Mouse CD54/ICAM1-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications: | ELISA/WB |
| Host: | Mammalian Cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Dilution Range: | Reconstitute in sterile water for a stock solution. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity: | Measured by its ability to support the adhesion of human peripheral blood acute lymphoblastic leukemia cells (HSB2). The ED50 for this effect is 0.075-0.6 µg/mL. |
| Gene Symbol: | Icam1 |
| Gene ID: | 15894 |
| Uniprot ID: | ICAM1_MOUSE |
| Immunogen: | Mus musculus (Mouse) |
| Immunogen Region: | Gln28-Asn485 |
| Post Translational Modifications | Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis. |
| Function | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. |
| Protein Name | Intercellular Adhesion Molecule 1Icam-1Mala-2Myd10Cd Antigen Cd54 |
| Database Links | Reactome: R-MMU-198933Reactome: -MMU-216083 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Intercellular Adhesion Molecule 1 proteinIcam-1 proteinMala-2 proteinMyd10 proteinCd Antigen Cd54 proteinIcam1 proteinIcam-1 protein |
Information sourced from Uniprot.org