| Function | Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including RAET1A, RAET1B, RAET1C, RAET1D, RAET1E, H60 and MULT1. |
| Protein Name | Nkg2-D Type Ii Integral Membrane ProteinKiller Cell Lectin-Like Receptor Subfamily K Member 1Nk Cell Receptor DNkg2-D-Activating Nk ReceptorCd Antigen Cd314 |
| Database Links | Reactome: R-MMU-198933Reactome: -MMU-2424491 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinColocalized With Hcst And Tyrobp On The Cell Surface |
| Alternative Protein Names | Nkg2-D Type Ii Integral Membrane Protein proteinKiller Cell Lectin-Like Receptor Subfamily K Member 1 proteinNk Cell Receptor D proteinNkg2-D-Activating Nk Receptor proteinCd Antigen Cd314 proteinKlrk1 proteinNkg2d protein |
Information sourced from Uniprot.org
