Mouse CD262/TRAIL-R2/DR5 protein (Recombinant-Active) (C-Fc) (STJP012796)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenMus musculus (Mouse)
General Information
| Short Description | Recombinant-Active-Mouse CD262/TRAIL-R2/DR5-C-Fc protein was developed from mammalian cells and has a target region of C-Fc. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in 20mM PB, 150mM NaCl, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8ยฐC for one week. Store at-20 to-80ยฐC for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/ยตg as determined by LAL test. |
Target Information
| Gene Symbol | Tnfrsf10b |
| Gene ID | 21933 |
| Uniprot ID | TR10B_MOUSE |
| Immunogen | Mus musculus (Mouse) |
| Immunogen Region | Asn53-Ser177 |
Additional Info
| Post Translational Modifications | (Microbial infection) Glycosylated at Arg-293 by S.typhimurium protein Ssek3. |
| Function | Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 10bDeath Receptor 5MkCd Antigen Cd262 |
| Database Links | Reactome: R-MMU-202733Reactome: -MMU-3371378Reactome: -MMU-5218900Reactome: -MMU-69416Reactome: -MMU-75158 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 10b proteinDeath Receptor 5 proteinMk proteinCd Antigen Cd262 proteinTnfrsf10b proteinDr5 proteinKiller protein |
Information sourced from Uniprot.org