Mouse CD262/TRAIL-R2/DR5 protein (Recombinant-Active) (C-Fc) (STJP012796)

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STJP012796-100
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Short Description :Recombinant-Active-Mouse CD262/TRAIL-R2/DR5-C-Fc protein was developed from mammalian cells and has a target region of C-Fc. For use in research applications.
Applications:ELISA/WB
Host:Mammalian Cells
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Dilution Range:Reconstitute in sterile water for a stock solution.
Formulation:Lyophilized from a 0.22 Mu m filtered solution in 20mM PB, 150mM NaCl, pH 7.4.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:< 1 EU/µg as determined by LAL test.
Gene Symbol:Tnfrsf10b
Gene ID:21933
Uniprot ID:TR10B_MOUSE
Immunogen:Mus musculus (Mouse)
Immunogen Region:Asn53-Ser177
Post Translational Modifications (Microbial infection) Glycosylated at Arg-293 by S.typhimurium protein Ssek3.
Function Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
Protein Name Tumor Necrosis Factor Receptor Superfamily Member 10b
Death Receptor 5
Mk
Cd Antigen Cd262
Database Links Reactome: R-MMU-202733
Reactome: -MMU-3371378
Reactome: -MMU-5218900
Reactome: -MMU-69416
Reactome: -MMU-75158
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Tumor Necrosis Factor Receptor Superfamily Member 10b protein
Death Receptor 5 protein
Mk protein
Cd Antigen Cd262 protein
Tnfrsf10b protein
Dr5 protein
Killer protein

Information sourced from Uniprot.org

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