Mouse CD257/BAFF/TNFSF13B/BLYS protein (Recombinant) (N-His) (STJP009954)
SPECIFICATIONS
HostE.coli
ImmunogenMus musculus (Mouse)
General Information
| Short Description | Recombinant-Mouse CD257/BAFF/TNFSF13B/BLYS-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | Tnfsf13b |
| Gene ID | 24099 |
| Uniprot ID | TN13B_MOUSE |
| Immunogen | Mus musculus (Mouse) |
| Immunogen Region | Ala127-Leu309 |
Additional Info
| Post Translational Modifications | The soluble form derives from the membrane form by proteolytic processing. Isoform 2 is not efficiently shed from the membrane unlike isoform 1. |
| Function | Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. |
| Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 13bB-Cell-Activating FactorBaffCd Antigen Cd257 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 13b - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 13b - Soluble Form |
| Database Links | Reactome: R-MMU-5668541Reactome: -MMU-5669034Reactome: -MMU-5676594 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinTumor Necrosis Factor Ligand Superfamily Member 13bSoluble Form: Secreted |
| Alternative Protein Names | Tumor Necrosis Factor Ligand Superfamily Member 13b proteinB-Cell-Activating Factor proteinBaff proteinCd Antigen Cd257 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 13b - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 13b - Soluble Form proteinTnfsf13b proteinBaff protein |
Information sourced from Uniprot.org