Mouse CD257/BAFF/TNFSF13B/BLYS protein (Recombinant-Active) (N-mFc) (STJP012884)

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STJP012884-100
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Host: Mammalian Cells
Applications: ELISA/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Mouse CD257/BAFF/TNFSF13B/BLYS-N-mFc protein was developed from mammalian cells and has a target region of N-mFc. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilized from a 0.22 Mu m filtered solution in 20mM Tris-HCl, 10% Trehalose, 2% Mannitol, 0.05% Tween 80, pH 8.0.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: < 1 EU/µg as determined by LAL test.
Gene Symbol: Tnfsf13b
Gene ID: 24099
Uniprot ID: TN13B_MOUSE
Immunogen Region: Ala127-Leu309
Immunogen: Mus musculus (Mouse)
Post Translational Modifications The soluble form derives from the membrane form by proteolytic processing. Isoform 2 is not efficiently shed from the membrane unlike isoform 1.
Function Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.
Protein Name Tumor Necrosis Factor Ligand Superfamily Member 13b
B-Cell-Activating Factor
Baff
Cd Antigen Cd257 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 13b - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 13b - Soluble Form
Database Links Reactome: R-MMU-5668541
Reactome: -MMU-5669034
Reactome: -MMU-5676594
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Tumor Necrosis Factor Ligand Superfamily Member 13b
Soluble Form: Secreted
Alternative Protein Names Tumor Necrosis Factor Ligand Superfamily Member 13b protein
B-Cell-Activating Factor protein
Baff protein
Cd Antigen Cd257 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 13b - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 13b - Soluble Form protein
Tnfsf13b protein
Baff protein

Information sourced from Uniprot.org

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