| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
<0.1 EU/Mu g |
| Gene Symbol: |
Cd163 |
| Gene ID: |
93671 |
| Uniprot ID: |
C163A_MOUSE |
| Immunogen Region: |
Met1-Thr1045 |
| Immunogen: |
Recombinant Mouse CD163 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Thr1045) of mouse CD163 (Accession #NP_444324.2) fused with 8×His tag at the C-terminus. |
| Immunogen Sequence: |
MGGHRMVLLGGAGSPGCKRF VHLGFFVVAVSSLLSASAVT NAPGEMKKELRLAGGENNCS GRVELKIHDKWGTVCSNGWS MNEVSVVCQQLGCPTSIKAL GWANSSAGSGYIWMDKVSCT GNESALWDCKHDGWGKHNCT HEKDAGVTCSDGSNLEMRLV NSAGHRCLGRVEIKFQGKWG TVCDDNFSKDHASVICKQLG CGSAISFSGSAKLGAGSGPI WLDDLACNGNESALWDCKH |
| Post Translational Modifications | A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs. |
| Function | Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. After shedding, the soluble form (sCD163) may play an anti-inflammatory role. |
| Protein Name | Scavenger Receptor Cysteine-Rich Type 1 Protein M130Cd Antigen Cd163 Cleaved Into - Soluble Cd163Scd163 |
| Database Links | Reactome: R-MMU-2168880 |
| Cellular Localisation | Soluble Cd163: SecretedCell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Scavenger Receptor Cysteine-Rich Type 1 Protein M130 proteinCd Antigen Cd163 Cleaved Into - Soluble Cd163 proteinScd163 proteinCd163 proteinM130 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
