• Mouse CD163 protein (Recombinant) (C-His) (STJP002051)

Mouse CD163 protein (Recombinant) (C-His) (STJP002051)

SKU:
STJP002051

£89.50 - £336.50
Current Stock:
Host: HEK293 cells
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse CD163-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Cd163
Gene ID: 93671
Uniprot ID: C163A_MOUSE
Immunogen Region: Met1-Thr1045
Immunogen: Recombinant Mouse CD163 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Thr1045) of mouse CD163 (Accession #NP_444324.2) fused with 8×His tag at the C-terminus.
Post Translational Modifications A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs.
Function Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. After shedding, the soluble form (sCD163) may play an anti-inflammatory role.
Protein Name Scavenger Receptor Cysteine-Rich Type 1 Protein M130
Cd Antigen Cd163 Cleaved Into - Soluble Cd163
Scd163
Database Links Reactome: R-MMU-2168880
Cellular Localisation Soluble Cd163: Secreted
Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Scavenger Receptor Cysteine-Rich Type 1 Protein M130 protein
Cd Antigen Cd163 Cleaved Into - Soluble Cd163 protein
Scd163 protein
Cd163 protein
M130 protein

Information sourced from Uniprot.org

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