Tissue Specificity | Expressed in the bone marrow, spleen and thymus in lymphoid organs, and the lung, kidney and heart in non-lymphoid organs. |
Function | Catalyzes both the synthesis of cyclic ADP-beta-D-ribose (cADPR) from NAD(+), and its hydrolysis to ADP-D-ribose (ADPR). Cyclic ADPR is known to serve as an endogenous second messenger that elicits calcium release from intracellular stores, and thus regulates the mobilization of intracellular calcium. May be involved in pre-B-cell growth. |
Protein Name | Adp-Ribosyl Cyclase/Cyclic Adp-Ribose Hydrolase 2Adp-Ribosyl Cyclase 2Antigen Bp3Bp-3 AlloantigenBone Marrow Stromal Antigen 1Bst-1Cyclic Adp-Ribose Hydrolase 2Cadpr Hydrolase 2Leukocyte Antigen 65Ly-65Cd Antigen Cd157 |
Database Links | Reactome: R-MMU-163125Reactome: -MMU-196807Reactome: -MMU-6798695 |
Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
Alternative Protein Names | Adp-Ribosyl Cyclase/Cyclic Adp-Ribose Hydrolase 2 proteinAdp-Ribosyl Cyclase 2 proteinAntigen Bp3 proteinBp-3 Alloantigen proteinBone Marrow Stromal Antigen 1 proteinBst-1 proteinCyclic Adp-Ribose Hydrolase 2 proteinCadpr Hydrolase 2 proteinLeukocyte Antigen 65 proteinLy-65 proteinCd Antigen Cd157 proteinBst1 proteinBp-3 proteinBp3 proteinLy65 protein |
Information sourced from Uniprot.org