Mouse CD141/THBD protein (Recombinant) (C-His) (STJP013812)

Name: Mouse CD141/THBD protein (Recombinant) (C-His) (STJP013812)
SKU: STJP013812-100
Price: 575.5 GBP
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostMammalian Cells

ConjugationUnconjugated

ImmunogenMus musculus (Mouse)

STJP013812-100

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Short Description	Recombinant-Mouse CD141/THBD-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Applications	ELISA/WB
Host	Mammalian Cells
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation	Unconjugated
Formulation	Supplied as a 0.22 Mu m filtered solution in 20mM Tris-HCl, 150mM NaCl, pH 8.0.
Storage Instruction	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin	< 1 EU/µg as determined by LAL test.

Function	Endothelial cell receptor that plays a critical role in regulating several physiological processes including hemostasis, coagulation, fibrinolysis, inflammation, and angiogenesis. Acts as a cofactor for thrombin activation of protein C/PROC on the surface of vascular endothelial cells leading to initiation of the activated protein C anticoagulant pathway. Also accelerates the activation of the plasma carboxypeptidase B2/CPB2, which catalyzes removal of C-terminal basic amino acids from its substrates including kinins or anaphylatoxins leading to fibrinolysis inhibition. Plays critical protective roles in changing the cleavage specificity of protease-activated receptor 1/PAR1, inhibiting endothelial cell permeability and inflammation. Suppresses inflammation distinctly from its anticoagulant cofactor activity by sequestering HMGB1 thereby preventing it from engaging cellular receptors such as RAGE and contributing to the inflammatory response.
Protein Name	Thrombomodulin Tm Fetomodulin Cd Antigen Cd141
Database Links	Reactome: R-MMU-140875 Reactome: -MMU-202733
Cellular Localisation	Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	Thrombomodulin protein Tm protein Fetomodulin protein Cd Antigen Cd141 protein Thbd protein

Information sourced from Uniprot.org