Mouse CD124/IL4R/IL-4R Alpha protein (Recombinant-Active) (C-Fc) (STJP012839)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenMus musculus (Mouse)
General Information
| Short Description | Recombinant-Active-Mouse CD124/IL4R/IL-4R Alpha-C-Fc protein was developed from mammalian cells and has a target region of C-Fc. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | Il4r |
| Gene ID | 16190 |
| Uniprot ID | IL4RA_MOUSE |
| Immunogen | Mus musculus (Mouse) |
| Immunogen Region | Ile26-Arg233 |
Additional Info
| Post Translational Modifications | On IL4 binding, phosphorylated on C-terminal tyrosine residues. Soluble IL4R can also be produced by proteolytic cleavage at the cell surface (shedding). |
| Function | Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. |
| Protein Name | Interleukin-4 Receptor Subunit AlphaIl-4 Receptor Subunit AlphaIl-4r Subunit AlphaIl-4r-AlphaIl-4raCd Antigen Cd124 Cleaved Into - Soluble Interleukin-4 Receptor Subunit AlphaSoluble Il-4 Receptor Subunit AlphaSoluble Il-4r-AlphaSil4ralpha/ProtIl-4-Binding ProteinIl4-Bp |
| Database Links | Reactome: R-MMU-6785807 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Protein Names | Interleukin-4 Receptor Subunit Alpha proteinIl-4 Receptor Subunit Alpha proteinIl-4r Subunit Alpha proteinIl-4r-Alpha proteinIl-4ra proteinCd Antigen Cd124 Cleaved Into - Soluble Interleukin-4 Receptor Subunit Alpha proteinSoluble Il-4 Receptor Subunit Alpha proteinSoluble Il-4r-Alpha proteinSil4ralpha/Prot proteinIl-4-Binding Protein proteinIl4-Bp proteinIl4r proteinIl4ra protein |
Information sourced from Uniprot.org