Mouse CD11b/ITGAM protein (Recombinant) (N-His) (STJP011036)
SPECIFICATIONS
HostE.coli
ImmunogenMus musculus (Mouse)
General Information
| Short Description | Recombinant-Mouse CD11b/ITGAM-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ItgamUniprot ID=ITAM_MOUSE" |
| Immunogen | Mus musculus (Mouse) |
| Immunogen Region | Gln615-Ala925 |
Additional Info
| Function | Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development. |
| Protein Name | Integrin Alpha-MCd11 Antigen-Like Family Member BCr-3 Alpha ChainCell Surface Glycoprotein Mac-1 Subunit AlphaLeukocyte Adhesion Receptor Mo1Cd Antigen Cd11b |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane Raft |
| Alternative Protein Names | Integrin Alpha-M proteinCd11 Antigen-Like Family Member B proteinCr-3 Alpha Chain proteinCell Surface Glycoprotein Mac-1 Subunit Alpha proteinLeukocyte Adhesion Receptor Mo1 proteinCd Antigen Cd11b proteinItgam protein |
Information sourced from Uniprot.org