Mouse CCL17/TARC protein (Recombinant) (C-His) (STJP003042)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Mouse CCL17/TARC Protein by Pichia expression system. The target protein is expressed with sequence (Ala24-Pro93) of Mouse CCL17/TARC (Accession #NP_035462.2) fused with a His tag at the C-terminus..
General Information
| Short Description | Recombinant-Mouse CCL17/TARC-C-His protein was developed in hek293 cells using the region Ala24-Pro93. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% Trehalose is added as protectant before lyophilisation. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | <1 EU/Mu g |
Target Information
| Gene Symbol | Ccl17 |
| Gene ID | 20295 |
| Uniprot ID | CCL17_MOUSE |
| Immunogen | Recombinant Mouse CCL17/TARC Protein by Pichia expression system. The target protein is expressed with sequence (Ala24-Pro93) of Mouse CCL17/TARC (Accession #NP_035462.2) fused with a His tag at the C-terminus.. |
| Immunogen Region | Ala24-Pro93 |
| Immunogen Sequence | LGCDLPQTHSLSNRRTLMIM AQMGRISPFSCLKDRHDFGF PQEEFDGNQFQKAQAISVLH EMIQQTFNLFSTKDSSATWD ETLLDKFYTELYQQLNDLEA CMMQEVGVEDTPLMNVDSIL TVRKYFQRITLYLTEKKYSP CAWEVVRAEIMRSFSLSANL QERLRRKE |
Additional Info
| Tissue Specificity | Expressed in primary and secondary lymphoid organs, where it is specifically produced by a subset of dendritic cells. Not expressed in the spleen. Constitutively expressed in thymus, as well as in the lung, skin and intestine. Not expressed in bone marrow-derived macrophages and activated B cells, nor in thymocytes. In the brain, predominantly expressed in a subset of hippocampal CA1 neurons. |
| Function | Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes. Therefore plays an important role in a wide range of inflammatory and immunological processes. Acts by binding to CCR4 at T-cell surface. Mediates GM-CSF/CSF2-driven pain and inflammation. In the brain, required to maintain the typical, highly branched morphology of hippocampal microglia under homeostatic conditions. May be important for the appropriate adaptation of microglial morphology and synaptic plasticity to acute lipopolysaccharide (LPS)-induced neuroinflammation. Plays a role in wound healing, mainly by inducing fibroblast migration into the wound. |
| Protein Name | C-C Motif Chemokine 17Abcd-2Cc Chemokine TarcSmall-Inducible Cytokine A17Thymus And Activation-Regulated Chemokine |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-C Motif Chemokine 17 proteinAbcd-2 proteinCc Chemokine Tarc proteinSmall-Inducible Cytokine A17 proteinThymus And Activation-Regulated Chemokine proteinCcl17 proteinTarc protein |
Information sourced from Uniprot.org