| Host: | HEK293 |
| Note: | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Mouse Cathepsin D-protein was developed from hek293. For use in research applications. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose. |
| Dilution Range: | Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers. |
| Storage Instruction: | Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin: | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA |
| Gene Symbol: | Ctsd |
| Gene ID: | 13033 |
| Uniprot ID: | CATD_MOUSE |
| Immunogen Region: | ILE21-LEU410 |
| Immunogen: | Optimized DNA sequence encoding mature chain of mouse Cathepsin D-CatD (ILE21-LEU410) including a C-terminal His tag was expressed in HEK293 cells. NA |
| Post Translational Modifications | N- and O-glycosylated. Undergoes proteolytic cleavage and activation by ADAM30. |
| Function | Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. |
| Protein Name | Cathepsin D |
| Database Links | Reactome: R-MMU-1442490Reactome: -MMU-2022377Reactome: -MMU-2132295Reactome: -MMU-6798695Reactome: -MMU-77387 |
| Cellular Localisation | LysosomeMelanosomeSecretedExtracellular Space |
| Alternative Protein Names | Cathepsin D proteinCtsd protein |
Information sourced from Uniprot.org