Mouse Calcitonin/CALCA protein (Recombinant) (C-hFc) (STJP020133)

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STJP020133-100
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Covered by St John's Laboratory Guarantee

Host: HEK293 Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation: Unconjugated
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1 EU/Mu g of the protein by LAL method.
Gene Symbol: Calca
Gene ID: 12310
Uniprot ID: CALCA_MOUSE
Immunogen Region: Val26-Asp119
Immunogen: Recombinant Mouse Calcitonin/CALCA Protein is produced by HEK293 Cells expression system. The target protein is expressed with sequence (Val26-Asp119) of mouse Calcitonin/CALCA (Accession #NP_001029126.1) fused with hFc tag at the C-terminus.
Immunogen Sequence: VPLRSILESSPGMATLSEEE VRLLAALVQDYMQMKARELE QEEEQEAEGSSVTAQKRSCN TATCVTHRLAGLLSRSGGVV KDNFVPTNVGSEAF
Tissue Specificity Detected in nerve cells of cerebrum, hippocampus and pons/midbrain in newborns, and only in nerve cells of pons/midbrain in adult.
Function CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex. Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex.
Protein Name Calcitonin Gene-Related Peptide 1
Cgrp1
Alpha-Type Cgrp
Calcitonin Gene-Related Peptide I
Cgrp-I
Database Links
Reactome: R-MMU-418555
Reactome: -MMU-419812
Cellular Localisation Secreted
Alternative Protein Names Calcitonin Gene-Related Peptide 1 protein
Cgrp1 protein
Alpha-Type Cgrp protein
Calcitonin Gene-Related Peptide I protein
Cgrp-I protein
Calca protein
Calc protein

Information sourced from Uniprot.org

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