Mouse c-Kit ligand/SCF/KITLG protein (Recombinant) (C-His) (STJP002693)

SKU:
STJP002693

£89.50 - £298.50
Current Stock:
Host: HEK293 cells
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse c-Kit ligand/SCF/KITLG-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: 1.Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 0.5-1.0 ng/mL, corresponding to a specific activity of 1.0×106-2.0×106 units/mg.2. Measured by its binding ability in a functional ELISA.Immo
Gene Symbol: Kitlg
Gene ID: 17311
Uniprot ID: SCF_MOUSE
Immunogen Region: Lys26-Ala189
Immunogen: Recombinant Mouse c-Kit ligand/SCF/KITLG Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Lys26-Ala189) of mouse SCF (Accession #NP_038626.1.) fused with a 6×His tag at the C-terminus.
Post Translational Modifications A soluble form is produced by proteolytic processing of isoform 1 in the extracellular domain.
Function Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Protein Name Kit Ligand
Hematopoietic Growth Factor Kl
Mast Cell Growth Factor
Mgf
Steel Factor
Stem Cell Factor
Scf
C-Kit Ligand Cleaved Into - Soluble Kit Ligand
Skitlg
Database Links Reactome: R-MMU-1257604
Reactome: -MMU-1433557
Reactome: -MMU-1433559
Reactome: -MMU-5673001
Reactome: -MMU-6811558
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Cytoplasm
Cytoplasm
Cytoskeleton
Cell Membrane
Cell Projection
Lamellipodium
Filopodium
Soluble Kit Ligand: Secreted
Alternative Protein Names Kit Ligand protein
Hematopoietic Growth Factor Kl protein
Mast Cell Growth Factor protein
Mgf protein
Steel Factor protein
Stem Cell Factor protein
Scf protein
C-Kit Ligand Cleaved Into - Soluble Kit Ligand protein
Skitlg protein
Kitlg protein
Kitl protein
Mgf protein
Sl protein
Slf protein

Information sourced from Uniprot.org

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