Mouse BK (Kininogen-1 Cleaved Into-Kininogen-1 Heavy Chain-Bradykinin-Kininogen-1 Light Chain) Antibody Pair (STJAP00331)

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STJAP00331-50
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Host: Rabbit/Rabbit
Applications: ELISA
Reactivity: Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description : This BK antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA.
Clonality : Polyclonal/Polyclonal
Conjugation: Unconjugated/Biotin
Formulation: Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Purification: Capture Purification: Protein A & Antigen Affinity.
Detection Purification: Protein A & Antigen Affinity.
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Gene Symbol: Kng1
Gene ID: 16644
Uniprot ID: KNG1_MOUSE
Immunogen: Capture immunogen: Recombinant Mouse BK protein.
Detection Immunogen: Recombinant Mouse BK protein.
Post Translational Modifications Bradykinin is released from kininogen by plasma kallikrein. Phosphorylated by FAM20C in the extracellular medium. Bradykinin: Bradykinin is inactivated by ACE, which removes the dipeptide Arg-Phe from its C-terminus.
Function Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII.HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes. LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting. Bradykinin: The active peptide bradykinin is a potent vasodilatator that is released from HMW-kininogen shows a variety of physiological effects: (A) influence in smooth muscle contraction, (B) induction of hypotension, (C) natriuresis and diuresis, (D) decrease in blood glucose level, (E) it is a mediator of inflammation and causes (E1) increase in vascular permeability, (E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action).
Protein Name Kininogen-1 Cleaved Into - Kininogen-1 Heavy Chain - Bradykinin - Kininogen-1 Light Chain
Cellular Localisation Secreted
Extracellular Space
Alternative Antibody Pair Names Kininogen-1 Cleaved Into - Kininogen-1 Heavy Chain - Bradykinin - Kininogen-1 Light Chain antibody pair
Kng1 antibody pair
Kng antibody pair

Information sourced from Uniprot.org

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