Mouse BDNF protein (Recombinant-Active) (Tag free) (STJP012838)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenMus musculus (Mouse)
General Information
| Short Description | Recombinant-Active-Mouse BDNF-Tag free protein was developed from e.coli and has a target region of Tag free. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.2 Mu m filtered solution in 20 mM PB, 250 mM NaCl, pH 7.2. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8ยฐC for one week. Store at-20 to-80ยฐC for twelve months from the date of receipt. |
| Endotoxin | < 0.01 EU/ยตg as determined by LAL test. |
Target Information
| Gene Symbol | Bdnf |
| Gene ID | 12064 |
| Uniprot ID | BDNF_MOUSE |
| Immunogen | Mus musculus (Mouse) |
| Immunogen Region | His129-Arg247 |
Additional Info
| Post Translational Modifications | Neurotrophic factor BDNF precursor form: N-glycosylated and glycosulfated, contrary to mature BDNF. Mature BDNF is produced by proteolytic removal of the propeptide, catalyzed by a FURIN family member. In addition, the precursor form is proteolytically cleaved within the propeptide, but this is not an obligatory intermediate for the production of mature BDNF. Can be converted into mature BDNF by plasmin (PLG). |
| Function | Important signaling molecule that activates signaling cascades downstream of NTRK2. During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. Neurotrophic factor BDNF precursor form: Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2. Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse. |
| Protein Name | Neurotrophic Factor Bdnf Precursor FormProbdnfBrain-Derived Neurotrophic Factor Cleaved Into - Neurotrophic Factor Bdnf |
| Database Links | Reactome: R-MMU-1257604Reactome: -MMU-6811558Reactome: -MMU-9026527Reactome: -MMU-9028731Reactome: -MMU-9032759 |
| Cellular Localisation | SecretedNeurotrophic Factor Bdnf Precursor Form: SecretedA Proportion Of Bdnf Is Secreted As Immature Precursor (Probdnf) |
| Alternative Protein Names | Neurotrophic Factor Bdnf Precursor Form proteinProbdnf proteinBrain-Derived Neurotrophic Factor Cleaved Into - Neurotrophic Factor Bdnf proteinBdnf protein |
Information sourced from Uniprot.org