Mouse Bax (Bcl2 Associated X Protein) Sandwich ELISA Kit (STJE0007437)
SPECIFICATIONS
General Information
| Short Description | This Bax Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse serum, plasma, tissue homogenates, cell lysates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Mouse |
| Sensitivity | 24.5pg/mL |
| Detection Limit | 62.5-4000pg/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 4.5 hrs |
Target Information
| Gene Symbol | Bax |
| Gene ID | 12028 |
| Uniprot ID | BAX_MOUSE |
| Sample Type | serum, plasma, tissue homogenates, cell lysates or other biological fluids. |
Additional Info
| Tissue Specificity | Expressed in a wide variety of tissues. |
| Post Translational Modifications | Ubiquitinated in the absence of XRCC6/Ku70. Ubiquitinated on Lys-128 and Lys-190. 'Lys-63'-linked polyubiquitin chains on Lys-128 are removed by USP12. |
| Function | Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. BAX deficiency leads to lymphoid hyperplasia and male sterility, because of the cessation of sperm production. |
| Protein Name | Apoptosis Regulator Bax |
| Database Links | Reactome: R-MMU-111457Reactome: -MMU-114294Reactome: -MMU-5620971Reactome: -MMU-6804114 |
| Cellular Localisation | Isoform Alpha: Mitochondrion Outer MembraneSingle-Pass Membrane ProteinCytoplasmNucleusColocalizes With 14-3-3 Proteins In The CytoplasmUnder Stress ConditionsUndergoes A Conformation Change That Causes Release From Jnk-Phosphorylated 14-3-3 Proteins And Translocation To The Mitochondrion MembraneIsoform Beta: CytoplasmIsoform Gamma: Cytoplasm |
| Alternative ELISA Names | Apoptosis Regulator Bax ELISA kitBax ELISA kit |
| output |
Information sourced from Uniprot.org