Mouse Basigin/CD147 protein (Recombinant) (C-His&Avi) (STJP001460)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Mouse Basigin/CD147 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala22-Ala211) of mouse CD147/EMMPRIN/Basigin (Accession #NP_033898.1) fused with a 6×His, Avi tag at the C-terminus.
General Information
| Short Description | Recombinant-Mouse Basigin/CD147-C-His&Avi protein was developed in hek293 cells using the region Ala22-Ala211. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | <0.1 EU/Mu g |
Target Information
| Gene Symbol | Bsg |
| Gene ID | 12215 |
| Uniprot ID | BASI_MOUSE |
| Immunogen | Recombinant Mouse Basigin/CD147 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala22-Ala211) of mouse CD147/EMMPRIN/Basigin (Accession #NP_033898.1) fused with a 6×His, Avi tag at the C-terminus. |
| Immunogen Region | Ala22-Ala211 |
| Immunogen Sequence | AAGTIQTSVQEVNSKTQLTC SLNSSGVDIVGHRWMRGGKV LQEDTLPDLHTKYIVDADDR SGEYSCIFLPEPVGRSEINV EGPPRIKVGKKSEHSSEGEL AKLVCKSDASYPPITDWFWF KTSDTGEEEAITNSTEANGK YVVVSTPEKSQLTISNLDVN VDPGTYVCNATNAQGTTRET ISLRVRSRMA |
Additional Info
| Post Translational Modifications | Isoform 1: N-glycosylated. Isoform 2: N-glycosylated. During spermatogenesis, probably deglycosylated during epididymal transit. |
| Function | Isoform 1: Essential for normal retinal maturation and development. Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors. In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors. Isoform 2: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells. Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling. Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA and KDR/VEGFR2 in endothelial cells. Plays an important role in spermatogenesis.mediates interactions between germ cells and Sertoli cell and is essential for the development/differentiation of germ cells to round spermatids. |
| Protein Name | BasiginBasic Immunoglobulin SuperfamilyHt7 AntigenMembrane Glycoprotein Gp42Cd Antigen Cd147 |
| Database Links | Reactome: R-MMU-1474228Reactome: -MMU-210991Reactome: -MMU-216083Reactome: -MMU-433692Reactome: -MMU-9749641 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinPhotoreceptor Inner SegmentCell ProjectionCiliumPhotoreceptor Outer SegmentIsoform 2: Cell MembraneEndoplasmic Reticulum MembraneBasolateral Cell Membrane |
| Alternative Protein Names | Basigin proteinBasic Immunoglobulin Superfamily proteinHt7 Antigen proteinMembrane Glycoprotein Gp42 proteinCd Antigen Cd147 proteinBsg protein |
Information sourced from Uniprot.org