• Mouse Basigin/CD147 protein (Recombinant) (C-His&Avi) (STJP001460)

Mouse Basigin/CD147 protein (Recombinant) (C-His&Avi) (STJP001460)

SKU:
STJP001460

£72.50 - £223.50
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Host: HEK293 cells
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse Basigin/CD147-C-His&Avi protein was developed from hek293 cells and has a target region of C-His&Avi. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Gene Symbol: Bsg
Gene ID: 12215
Uniprot ID: BASI_MOUSE
Immunogen: Recombinant Mouse Basigin/CD147 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala22-Ala211) of mouse CD147/EMMPRIN/Basigin (Accession #NP_033898.1) fused with a 6×His, Avi tag at the C-terminus.
Post Translational Modifications Isoform 1: N-glycosylated. Isoform 2: N-glycosylated. During spermatogenesis, probably deglycosylated during epididymal transit.
Function Isoform 1: Essential for normal retinal maturation and development. Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors. In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors. Isoform 2: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells. Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling. Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA and KDR/VEGFR2 in endothelial cells. Plays an important role in spermatogenesis.mediates interactions between germ cells and Sertoli cell and is essential for the development/differentiation of germ cells to round spermatids.
Protein Name Basigin
Basic Immunoglobulin Superfamily
Ht7 Antigen
Membrane Glycoprotein Gp42
Cd Antigen Cd147
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Photoreceptor Inner Segment
Cell Projection
Cilium
Photoreceptor Outer Segment
Isoform 2: Cell Membrane
Endoplasmic Reticulum Membrane
Basolateral Cell Membrane
Alternative Protein Names Basigin protein
Basic Immunoglobulin Superfamily protein
Ht7 Antigen protein
Membrane Glycoprotein Gp42 protein
Cd Antigen Cd147 protein
Bsg protein

Information sourced from Uniprot.org

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