| Tissue Specificity | High expression in pancreatic islets. Expressed at much lower levels in the pituitary, colon, and ovaries and is nearly absent from all the other tissues. |
| Post Translational Modifications | Undergoes autoproteolytic cleavage. Glycosylated. |
| Function | Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells. |
| Protein Name | Beta-Secretase 2Aspartyl Protease 1Asp1Asp 1Beta-Site Amyloid Precursor Protein Cleaving Enzyme 2Beta-Site App Cleaving Enzyme 2Memapsin-1Membrane-Associated Aspartic Protease 1Theta-Secretase |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinGolgi ApparatusEndoplasmic ReticulumEndosomeMelanosomeColocalizes With Pmel In Stage I And Ii Melanosomes |
| Alternative Protein Names | Beta-Secretase 2 proteinAspartyl Protease 1 proteinAsp1 proteinAsp 1 proteinBeta-Site Amyloid Precursor Protein Cleaving Enzyme 2 proteinBeta-Site App Cleaving Enzyme 2 proteinMemapsin-1 proteinMembrane-Associated Aspartic Protease 1 proteinTheta-Secretase proteinBace2 protein |
Information sourced from Uniprot.org
