| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA.Immobilized Mouse B7-H5/VISTA at 0.5 Mu g/mL (100 Mu L/well) can bind B7-H5/VISTA Rabbit pAb with a linear range of 0.01-2.6 ng/mL. |
| Gene Symbol: |
Vsir |
| Gene ID: |
74048 |
| Uniprot ID: |
VISTA_MOUSE |
| Immunogen: |
Recombinant Mouse B7-H5/Gi24/VISTA Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Phe33-Ala191) of Mouse VISTA (Accession #NP_083008.1) fused with an 6×His tag at the C-terminus. |
| Immunogen Sequence: |
FKVTTPYSLYVCPEGQNATL TCRILGPVSKGHDVTIYKTW YLSSRGEVQMCKEHRPIRNF TLQHLQHHGSHLKANASHD QPQKHGLELASDHHGNFSIT LRNVTPRDSGLYCCLVIELK N HHPEQRFYGSMELQVQAG KGSGSTCMASNEQDSDSITA A |
| Post Translational Modifications | At the cell surface, may be cleaved by MMP14. N-glycosylated. |
| Function | Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. May stimulate MMP14-mediated MMP2 activation. |
| Protein Name | V-Type Immunoglobulin Domain-Containing Suppressor Of T-Cell ActivationPlatelet Receptor Gi24V-Set Domain-Containing Immunoregulatory ReceptorV-Set Immunoregulatory Receptor |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | V-Type Immunoglobulin Domain-Containing Suppressor Of T-Cell Activation proteinPlatelet Receptor Gi24 proteinV-Set Domain-Containing Immunoregulatory Receptor proteinV-Set Immunoregulatory Receptor proteinVsir proteinDies1 proteinPD-1H proteinVISTA protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
