| Short Description : | Recombinant-Mouse Angiopoietin-2/ANG-2/ANGPT2-C-6His protein was developed in hek293 cells using the region Lys275-Phe496. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <0.001 EU/Mu g |
| Gene Symbol: | Angpt2 |
| Gene ID: | 11601 |
| Uniprot ID: | ANGP2_MOUSE |
| Immunogen: | Recombinant Mouse Angiopoietin-2/ANG-2/ANGPT2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys275-Phe496) of mouse Angiopoietin-2/ANG-2/ANGPT2 (Accession #NP_031452.2) fused with a 6×His tag at |
| Immunogen Region: | Lys275-Phe496 |
| Immunogen Sequence: | KEEQTTFRDCAEIFKSGLTT SGIYTLTFPNSTEEIKAYCD MDVGGGGWTVIQHREDGSVD FQRTWKEYKEGFGSPLGEYW LGNEFVSQLTGQHRYVLKIQ LKDWEGNEAHSLYDHFYLAG EESNYRIHLTGLTGTAGKIS SISQPGSDFSTKDSDNDKCI CKCSQMLSGGWWFDACGPSN LNGQYYPQKQNTNKFNGIKW YYWKGSGYSLKATTMMIRPA DF |
| Function | Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Involved in the regulation of lymphangiogenesis. |
| Protein Name | Angiopoietin-2Ang-2 |
| Database Links | Reactome: R-MMU-210993 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Angiopoietin-2 proteinAng-2 proteinAngpt2 proteinAgpt2 protein |
Information sourced from Uniprot.org
