| Host: | Mammalian Cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Active-Mouse ACVR2A/ACTR-IIA-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | <0.1 EU/Mu g of the protein by the LAL method. |
| Gene Symbol: | Acvr2a |
| Gene ID: | 11480 |
| Uniprot ID: | AVR2A_MOUSE |
| Immunogen Region: | Met1-Pro134 |
| Immunogen: | Mus musculus (Mouse) |
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6. |
| Protein Name | Activin Receptor Type-2aActivin Receptor Type IiaActr-Iia |
| Database Links | Reactome: R-MMU-1502540Reactome: -MMU-201451Reactome: -MMU-9839406 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Activin Receptor Type-2a proteinActivin Receptor Type Iia proteinActr-Iia proteinAcvr2a proteinAcvr2 protein |
Information sourced from Uniprot.org