| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
MINPP1 Blocking Peptide for STJ501756 is synthetically produced from the 1-100 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
MINPP1 |
| Gene ID: |
9562 |
| Uniprot ID: |
MINP1_HUMAN |
| Immunogen Region: |
1-100 |
| Specificity: |
This blocking peptide is recommended for use in combination with MINPP1 antibody, STJ501756 |
| Immunogen: |
Synthetic peptide taken within amino acid region 1-100 on rat MINPP1 protein |
| Post Translational Modifications | N-glycosylated. |
| Function | Multiple inositol polyphosphate phosphatase that hydrolyzes 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP52OH) and 1D-myo-inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal chelators which control many aspects of cell physiology. Has a weak in vitro activity towards 1D-myo-inositol 1,4,5-trisphosphate which is unlikely to be physiologically relevant. By regulating intracellular inositol polyphosphates pools, which act as metal chelators, it may control the availability of intracellular calcium and iron, which are important for proper neuronal development and homeostasis. May have a dual substrate specificity, and function as a 2,3-bisphosphoglycerate 3-phosphatase hydrolyzing 2,3-bisphosphoglycerate to 2-phosphoglycerate. 2,3-bisphosphoglycerate (BPG) is formed as part of the Rapoport-Luebering glycolytic bypass and is a regulator of systemic oxygen homeostasis as the major allosteric effector of hemoglobin. |
| Peptide Name | Multiple Inositol Polyphosphate Phosphatase 12 -3-Bisphosphoglycerate 3-Phosphatase2 -3-Bpg Phosphatase |
| Database Links | Reactome: R-HSA-1855231 |
| Cellular Localisation | Endoplasmic Reticulum LumenSecretedCell MembraneAlso Associated With The Plasma Membrane In Erythrocytes |
| Alternative Peptide Names | Multiple Inositol Polyphosphate Phosphatase 1 protein2 -3-Bisphosphoglycerate 3-Phosphatase protein2 -3-Bpg Phosphatase proteinMINPP1 proteinMIPP proteinUNQ900 proteinPRO1917 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
