| Applications: | WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | MERTK Positive Control for STJ501767 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: | WB: 1:750 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | MTAP |
| Gene ID: | 4507 |
| Uniprot ID: | MTAP_HUMAN |
| Specificity: | This is positive control is recommended for use in combination with MERTK antibody STJ501767. |
| Tissue Specificity | Ubiquitously expressed. |
| Function | Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. |
| Peptide Name | S-Methyl-5'-Thioadenosine Phosphorylase 5'-Methylthioadenosine Phosphorylase Mta Phosphorylase Mtap Mtapase |
| Database Links | Reactome: R-HSA-1237112 Reactome: R-HSA-8950505 |
| Cellular Localisation | Cytoplasm Nucleus |
| Alternative Peptide Names | S-Methyl-5'-Thioadenosine Phosphorylase protein 5'-Methylthioadenosine Phosphorylase protein Mta Phosphorylase protein Mtap protein Mtapase protein MTAP protein MSAP protein |
Information sourced from Uniprot.org