Tissue Specificity | Expressed in melanocytes. Expressed in corticoadrenal tissue. |
Function | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes. |
Peptide Name | Melanocyte-Stimulating Hormone ReceptorMsh-RMelanocortin Receptor 1Mc1-R |
Database Links | Reactome: R-HSA-375276Reactome: R-HSA-418555Reactome: R-HSA-9856649 |
Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
Alternative Peptide Names | Melanocyte-Stimulating Hormone Receptor proteinMsh-R proteinMelanocortin Receptor 1 proteinMc1-R proteinMC1R proteinMSHR protein |
Information sourced from Uniprot.org