| Applications: | Immunodepletion/Immunocompetition |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | MC3 Receptor Blocking Peptide is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | MC1R |
| Gene ID: | 4157 |
| Uniprot ID: | MSHR_HUMAN |
| Immunogen: | Synthetic peptide corresponding to unique amino acid sequences on MC3r protein. |
| Tissue Specificity | Expressed in melanocytes. Expressed in corticoadrenal tissue. |
| Function | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes. |
| Peptide Name | Melanocyte-Stimulating Hormone Receptor Msh-R Melanocortin Receptor 1 Mc1-R |
| Database Links | Reactome: R-HSA-375276 Reactome: R-HSA-418555 Reactome: R-HSA-9856649 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
| Alternative Peptide Names | Melanocyte-Stimulating Hormone Receptor protein Msh-R protein Melanocortin Receptor 1 protein Mc1-R protein MC1R protein MSHR protein |
Information sourced from Uniprot.org