| Tissue Specificity | High expression in heart and brain. |
| Post Translational Modifications | Phosphorylated at Ser-186 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites. |
| Function | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle. |
| Peptide Name | Mitogen-Activated Protein Kinase 4Map Kinase 4Mapk 4Extracellular Signal-Regulated Kinase 4Erk-4Map Kinase Isoform P63P63-Mapk |
| Database Links | Reactome: R-HSA-5687128 |
| Cellular Localisation | CytoplasmNucleusTranslocates To The Cytoplasm Following Interaction With Mapkapk5 |
| Alternative Peptide Names | Mitogen-Activated Protein Kinase 4 proteinMap Kinase 4 proteinMapk 4 proteinExtracellular Signal-Regulated Kinase 4 proteinErk-4 proteinMap Kinase Isoform P63 proteinP63-Mapk proteinMAPK4 proteinERK4 proteinPRKM4 protein |
Information sourced from Uniprot.org
