MAP3K12 Positive Control for STJ500392 peptide (STJ504443)

Name: MAP3K12 Positive Control for STJ500392 peptide (STJ504443)
SKU: STJ504443-5
Price: 370.2 EUR
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

STJ504443-5

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Short Description	MAP3K12 Positive Control for STJ500392 is synthetically produced from the sequence and is suitable for use in western blot applications.
Applications	WB
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Dilution Range	WB: 1:500
Formulation	Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Storage Instruction	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol	MAP3K12
Gene ID	7786
Uniprot ID	M3K12_HUMAN
Specificity	This is positive control is recommended for use in combination with MAP3K12 antibody STJ500392.

Tissue Specificity	Highly expressed in brain and kidney.
Post Translational Modifications	Autophosphorylated on Ser/Thr. Phosphorylated in cytosol under basal conditions and dephosphorylated when membrane-associated. The activity of MAP3K12 can be regulated through its proteasomal degradation. APOE, through a receptor-mediated mechanism, activates MAP3K12 by preventing its proteasomal degradation.
Function	Part of a non-canonical MAPK signaling pathway. Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1. May be an activator of the JNK/SAPK pathway.
Peptide Name	Mitogen-Activated Protein Kinase Kinase Kinase 12 Dual Leucine Zipper Bearing Kinase Dlk Leucine-Zipper Protein Kinase Zpk Mapk-Upstream Kinase Muk Mixed Lineage Kinase
Cellular Localisation	Cytoplasm Cell Membrane Behaves Essentially As An Integral Membrane Protein
Alternative Peptide Names	Mitogen-Activated Protein Kinase Kinase Kinase 12 protein Dual Leucine Zipper Bearing Kinase protein Dlk protein Leucine-Zipper Protein Kinase protein Zpk protein Mapk-Upstream Kinase protein Muk protein Mixed Lineage Kinase protein MAP3K12 protein ZPK protein

Information sourced from Uniprot.org