| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Legumain Blocking Peptide is synthetically produced from the 100-150 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
LGMN |
| Gene ID: |
5641 |
| Uniprot ID: |
LGMN_HUMAN |
| Immunogen Region: |
100-150 |
| Immunogen: |
Synthetic peptide taken within amino acid region 100-150 on human Legumain protein. |
| Tissue Specificity | Ubiquitous. Particularly abundant in kidney, heart and placenta. |
| Post Translational Modifications | Activated by autocatalytic processing at pH 4. |
| Function | Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation. |
| Peptide Name | LegumainAsparaginyl EndopeptidaseAepProtease - Cysteine 1 |
| Database Links | Reactome: R-HSA-1679131Reactome: R-HSA-196791Reactome: R-HSA-2132295 |
| Cellular Localisation | Lysosome |
| Alternative Peptide Names | Legumain proteinAsparaginyl Endopeptidase proteinAep proteinProtease - Cysteine 1 proteinLGMN proteinPRSC1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
