KIRREL Blocking Peptide peptide (STJ504407)

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STJ504407-250
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Short Description :KIRREL Blocking Peptide is synthetically produced from the 650-700 sequence and is suitable for use in western blot applications.
Applications:Immunodepletion/Immunocompetition
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation:Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol:Kirrel1
Gene ID:170643
Uniprot ID:KIRR1_MOUSE
Immunogen:Synthetic peptide taken within amino acid region 650-700 on mouse Neph1 protein. Binds to extracellular portion.
Immunogen Region:650-700
Tissue Specificity Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.
Post Translational Modifications Phosphorylation probably regulates the interaction with NPHS2. Phosphorylated at Tyr-637 and Tyr-638 by FYN, leading to GRB2 binding. N-glycosylated.
Function Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.
Peptide Name Kin Of Irre-Like Protein 1
Kin Of Irregular Chiasm-Like Protein 1
Nephrin-Like Protein 1
Database Links Reactome: R-MMU-373753
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Predominantly Located At Podocyte Slit Diaphragm
Alternative Peptide Names Kin Of Irre-Like Protein 1 protein
Kin Of Irregular Chiasm-Like Protein 1 protein
Nephrin-Like Protein 1 protein
Kirrel1 protein
Kirrel protein
Neph1 protein

Information sourced from Uniprot.org

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