| Applications: | WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | KIF13A Positive Control for STJ501535 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: | WB: 1:500 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | KIF13A |
| Gene ID: | 63971 |
| Uniprot ID: | KI13A_HUMAN |
| Specificity: | This is positive control is recommended for use in combination with KIF13A antibody STJ501535. |
| Tissue Specificity | Widely expressed, with highest levels in heart, brain and skeletal muscle. |
| Function | Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abscission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. |
| Peptide Name | Kinesin-Like Protein Kif13a Kinesin-Like Protein Rbkin |
| Database Links | Reactome: R-HSA-390471 |
| Cellular Localisation | Cytoplasm Cytoskeleton Microtubule Organizing Center Centrosome Midbody Endosome Membrane Golgi Apparatus Membrane Recruited To The Midbody During Cytokinesis |
| Alternative Peptide Names | Kinesin-Like Protein Kif13a protein Kinesin-Like Protein Rbkin protein KIF13A protein RBKIN protein |
Information sourced from Uniprot.org