| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
KDM4C/GASC1/JMJD2C Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: |
WB: 1:2, 500-1:5, 000 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Tissue Specificity | Overexpressed in several esophageal squamous cell carcinomas (ESCs). |
| Function | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. |
| Peptide Name | Lysine-Specific Demethylase 4cGene Amplified In Squamous Cell Carcinoma 1 ProteinGasc-1 ProteinJmjc Domain-Containing Histone Demethylation Protein 3cJumonji Domain-Containing Protein 2cHistone H3-Trimethyl-L-Lysine(9 Demethylase 4c |
| Database Links | Reactome: R-HSA-3214842Reactome: R-HSA-5625886 |
| Cellular Localisation | Nucleus |
| Alternative Peptide Names | Lysine-Specific Demethylase 4c proteinGene Amplified In Squamous Cell Carcinoma 1 Protein proteinGasc-1 Protein proteinJmjc Domain-Containing Histone Demethylation Protein 3c proteinJumonji Domain-Containing Protein 2c proteinHistone H3-Trimethyl-L-Lysine(9 Demethylase 4c proteinKDM4C proteinGASC1 proteinJHDM3C proteinJMJD2C proteinKIAA0780 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
