| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
JTB Blocking Peptide for STJ505928 is synthetically produced from the 100-146 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
JTB |
| Gene ID: |
10899 |
| Uniprot ID: |
JTB_HUMAN |
| Immunogen Region: |
100-146 |
| Specificity: |
This blocking peptide is recommended for use in combination with JTB antibody, STJ505928 |
| Immunogen: |
Synthetic peptide taken within amino acid region 100-146 on human Jumping Translocation Breakpoint protein. |
| Function | Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential. |
| Peptide Name | Protein JtbJumping Translocation Breakpoint ProteinProstate Androgen-Regulated ProteinPar Protein |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinMitochondrionCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleDetected At The Centrosome And Along Spindle Fibers During Prophase And MetaphaseDetected At The Midbody During Telophase |
| Alternative Peptide Names | Protein Jtb proteinJumping Translocation Breakpoint Protein proteinProstate Androgen-Regulated Protein proteinPar Protein proteinJTB proteinHSPC222 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
