| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
IKAP Positive Control for STJ501408 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: |
WB: 1:500 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Elp1 |
| Gene ID: |
230233 |
| Uniprot ID: |
ELP1_MOUSE |
| Specificity: |
This is positive control is recommended for use in combination with IKAP antibody STJ501408. |
| Tissue Specificity | In the testis, expression is restricted to germ cells during spermatogenesis with no expression detected in somatic cells such as Sertoli cells or Leydig cells (at protein level). In the ovary, expressed in oocytes of primary, secondary and antral follicles (at protein level). Widely expressed in adult tissues with highest levels in brain and also expressed at all embryonic stages. |
| Post Translational Modifications | Phosphorylated. |
| Function | Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA. May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK). |
| Peptide Name | Elongator Complex Protein 1Elp1Ikappab Kinase Complex-Associated ProteinIkk Complex-Associated Protein |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Peptide Names | Elongator Complex Protein 1 proteinElp1 proteinIkappab Kinase Complex-Associated Protein proteinIkk Complex-Associated Protein proteinElp1 proteinIkap proteinIkbkap protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
