Human ZNF207 protein (Recombinant) (N-GST & C-His) (STJP015286)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ZNF207-N-GST & C-His protein was developed from e.coli for the region N-GST & C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | ZNF207 |
| Gene ID | 7756 |
| Uniprot ID | ZN207_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asp21-Ser113 |
Additional Info
| Function | Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks. Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3. According to another report, the stabilization is independent of the proteasome. |
| Protein Name | Bub3-Interacting And Glebs Motif-Containing Protein Znf207BugzHbugzZinc Finger Protein 207 |
| Database Links | |
| Cellular Localisation | NucleusChromosomeCentromereKinetochoreCytoplasmCytoskeletonSpindleLocalizes Primarily To The Nucleus In InterphaseConcentrates At Kinetochores Prior To Nuclear Envelope Breakdown And During Early PrometaphaseAnd Disappears From Kinetochores Upon Microtubule-Binding |
| Alternative Protein Names | Bub3-Interacting And Glebs Motif-Containing Protein Znf207 proteinBugz proteinHbugz proteinZinc Finger Protein 207 proteinZNF207 proteinBUGZ protein |
Information sourced from Uniprot.org