| Function | Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. Acts as an adapter protein and facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner. |
| Protein Name | ProtrudinSpastic Paraplegia 33 ProteinZinc Finger Fyve Domain-Containing Protein 27 |
| Cellular Localisation | Recycling Endosome MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneCell ProjectionGrowth Cone MembraneLocalizes At Both Dendrites And AxonsLocalizes To Endoplasmic Reticulum Tubular Network |
| Alternative Protein Names | Protrudin proteinSpastic Paraplegia 33 Protein proteinZinc Finger Fyve Domain-Containing Protein 27 proteinZFYVE27 proteinSPG33 protein |
Information sourced from Uniprot.org
