Human ZFYVE27 protein (Recombinant) (N-GST & C-His) (STJP007643)

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STJP007643
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ZFYVE27-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ZFYVE27
Gene ID: 118813
Uniprot ID: ZFY27_HUMAN
Immunogen Region: Lys361-Lys411
Immunogen: Homo sapiens (Human)
Function Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. Acts as an adapter protein and facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner.
Protein Name Protrudin
Spastic Paraplegia 33 Protein
Zinc Finger Fyve Domain-Containing Protein 27
Cellular Localisation Recycling Endosome Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum Membrane
Cell Projection
Growth Cone Membrane
Localizes At Both Dendrites And Axons
Localizes To Endoplasmic Reticulum Tubular Network
Alternative Protein Names Protrudin protein
Spastic Paraplegia 33 Protein protein
Zinc Finger Fyve Domain-Containing Protein 27 protein
ZFYVE27 protein
SPG33 protein

Information sourced from Uniprot.org