Human ZEB1 protein (Recombinant) (N-GST & C-His) (STJP007335)

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STJP007335
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ZEB1-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ZEB1
Gene ID: 6935
Uniprot ID: ZEB1_HUMAN
Immunogen Region: Ser583-Glu643
Immunogen: Homo sapiens (Human)
Post Translational Modifications Ubiquitinated, leading to degradation in a proteasome-dependent manner. Deubiquitinated by USP51, leading to stabilization.
Function Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region.
Protein Name Zinc Finger E-Box-Binding Homeobox 1
Nil-2-A Zinc Finger Protein
Negative Regulator Of Il2
Transcription Factor 8
Tcf-8
Database Links Reactome: R-HSA-6785807
Cellular Localisation Nucleus
Alternative Protein Names Zinc Finger E-Box-Binding Homeobox 1 protein
Nil-2-A Zinc Finger Protein protein
Negative Regulator Of Il2 protein
Transcription Factor 8 protein
Tcf-8 protein
ZEB1 protein
AREB6 protein
TCF8 protein

Information sourced from Uniprot.org

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