Human ZC3H12D protein (Recombinant) (N-His) (STJP009038)

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STJP009038
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ZC3H12D-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ZC3H12D
Gene ID: 340152
Uniprot ID: ZC12D_HUMAN
Immunogen Region: Arg90-Pro231
Immunogen: Homo sapiens (Human)
Function May regulate cell growth likely by suppressing RB1 phosphorylation. May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages. Serve as a tumor suppressor in certain leukemia cells. Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation.
Protein Name Probable Ribonuclease Zc3h12d
Mcp-Induced Protein 4
Transformed Follicular Lymphoma
Zinc Finger Ccch Domain-Containing Protein 12d
P34
Cellular Localisation Cytoplasm
P-Body
Colocalizes With Zc3h12a In Gw Bodies (Gwbs)
Isoform 1: Cytoplasm
Localized As Discrete Granules
Colocalized With Mrna-Processing Body Markers
Ago2 And Dcp1a
But Not With A Stress Granule Maker
Tia1
In The Cytoplasm
Isoform 3: Cytoplasm
Nucleus
Alternative Protein Names Probable Ribonuclease Zc3h12d protein
Mcp-Induced Protein 4 protein
Transformed Follicular Lymphoma protein
Zinc Finger Ccch Domain-Containing Protein 12d protein
P34 protein
ZC3H12D protein
C6orf95 protein
MCPIP4 protein
TFL protein

Information sourced from Uniprot.org

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