Human YEATS4 protein (Recombinant) (N-GST) (STJP009998)

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STJP009998
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human YEATS4-N-GST protein was developed from e. coli and has a target region of N-GST. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: YEATS4
Gene ID: 8089
Uniprot ID: YETS4_HUMAN
Immunogen Region: Met1-Ile227
Immunogen: Homo sapiens (Human)
Function Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac). Also able to recognize and bind crotonylated histone H3. May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ).additional evidences are however required to confirm this result in vivo. Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions: recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z. H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell.
Protein Name Yeats Domain-Containing Protein 4
Glioma-Amplified Sequence 41
Gas41
Numa-Binding Protein 1
Nubi-1
Nubi1
Database Links Reactome: R-HSA-3214847
Reactome: R-HSA-8866907
Cellular Localisation Nucleus
Alternative Protein Names Yeats Domain-Containing Protein 4 protein
Glioma-Amplified Sequence 41 protein
Gas41 protein
Numa-Binding Protein 1 protein
Nubi-1 protein
Nubi1 protein
YEATS4 protein
GAS41 protein

Information sourced from Uniprot.org

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