| Post Translational Modifications | Autoubiquitinated. Ubiquitinated by the SCF(FBXL15) complex, leading to its degradation by the proteasome. |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation.in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation.in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2.the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation. |
| Protein Name | Nedd4-Like E3 Ubiquitin-Protein Ligase Wwp2Atrophin-1-Interacting Protein 2Aip2Hect-Type E3 Ubiquitin Transferase Wwp2Ww Domain-Containing Protein 2 |
| Database Links | Reactome: R-HSA-8948751Reactome: R-HSA-9013406Reactome: R-HSA-9013409Reactome: R-HSA-9013420Reactome: R-HSA-9013507 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Nedd4-Like E3 Ubiquitin-Protein Ligase Wwp2 proteinAtrophin-1-Interacting Protein 2 proteinAip2 proteinHect-Type E3 Ubiquitin Transferase Wwp2 proteinWw Domain-Containing Protein 2 proteinWWP2 protein |
Information sourced from Uniprot.org
