Human WTAP protein (Recombinant) (N-His) (STJP005420)

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STJP005420
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human WTAP-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: WTAP
Gene ID: 9589
Uniprot ID: FL2D_HUMAN
Immunogen Region: Met1-Asp150
Immunogen: Homo sapiens (Human)
Function Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Required for accumulation of METTL3 and METTL14 to nuclear speckle. Acts as a mRNA splicing regulator. Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes.
Protein Name Pre-Mrna-Splicing Regulator Wtap
Female-Lethal(2d Homolog
Hfl(2d
Wt1-Associated Protein
Wilms Tumor 1-Associating Protein
Database Links Reactome: R-HSA-72203
Cellular Localisation Nucleus Speckle
Nucleus
Nucleoplasm
Cytoplasm
Mainly Nuclear With Some Fraction Located In The Cytoplasm
Zc3h13 Is Required To Anchor Component Of The Macom Subcomplex
Such As Virma
In The Nucleus
Alternative Protein Names Pre-Mrna-Splicing Regulator Wtap protein
Female-Lethal(2d Homolog protein
Hfl(2d protein
Wt1-Associated Protein protein
Wilms Tumor 1-Associating Protein protein
WTAP protein
KIAA0105 protein

Information sourced from Uniprot.org

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