SDS-PAGE gel of recombinant human WARS protein under reducing conditions stained with Coomassie blue

Human WARS protein (Recombinant) (His-Tag) (STJP016767)

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STJP016767
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Short Description :Recombinant-Human WARS-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 1mM DTT, 10% Glycerol
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:WARS1
Gene ID:7453
Uniprot ID:SYWC_HUMAN
Accession Number:NP_776049
Immunogen:Human
Immunogen Region:1-471aa
Immunogen Sequence: MPNSEPASLL ELFNSIATQG ELVRSLKAGN ASKDEIDSAV KMLVSLKMSY KAAAGEDYKA DCPPGNPAPT SNHGPDATEA EEDFVDPWTV QTSSAKGIDY DKLIVRFGSS KIDKELINRI ERATGQRPHH FLRRGIFFSH RDMNQVLDAY ENKKPFYLYT GRGPSSEAMH VGHLIPFIFT KWLQDVFNVP LVIQMTDDEK YLWKDL
Post Translational Modifications Proteolytic cleavage generates 2 forms.T1-TrpRS and T2-TrpRS.
Function Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of the tRNA(Trp). Isoform 1: Has no angiostatic activity. T2-TrpRS: Possesses an angiostatic activity but has no aminoacylation activity. Inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression. Isoform 2: Has an angiostatic activity.
Protein Name Tryptophan--Trna Ligase - Cytoplasmic
Interferon-Induced Protein 53
Ifp53
Tryptophanyl-Trna Synthetase
Trprs
Hwrs Cleaved Into - T1-Trprs - T2-Trprs
Database Links Reactome: R-HSA-379716
Cellular Localisation Cytoplasm
Alternative Protein Names Tryptophan--Trna Ligase - Cytoplasmic protein
Interferon-Induced Protein 53 protein
Ifp53 protein
Tryptophanyl-Trna Synthetase protein
Trprs protein
Hwrs Cleaved Into - T1-Trprs - T2-Trprs protein
WARS1 protein
IFI53 protein
WARS protein
WRS protein

Information sourced from Uniprot.org

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