| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | TPBG |
| Gene ID: | 7162 |
| Uniprot ID: | TPBG_HUMAN |
| Immunogen: | Recombinant Human WAIF1/5T4/TPBG Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser32-Ser355) of human TPBG/5T4 (Accession #NP_006661.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: | SSPTSSASSFSSSAPFLASA VSAQPPLPDQCPALCECSEA ARTVKCVNRNLTEVPTDLPA YVRNLFLTGNQLAVLPAGAF ARRPPLAELAALNLSGSRLD EVRAGAFEHLPSLRQLDLSH NPLADLSPFAFSGSNASVSA PSPLVELILNHIVPPEDERQ NRSFEGMVVAALLAGRALQG LRRLELASNHFLYLPRDVLA QLPSLRHLDLSNNSLVSLTY VSFRNLTHLESLHLEDNAL |
| Post Translational Modifications | Highly glycosylated. |
| Function | May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. |
| Protein Name | Trophoblast Glycoprotein5t4 Oncofetal Antigen5t4 Oncofetal Trophoblast Glycoprotein5t4 Oncotrophoblast GlycoproteinM6p1Wnt-Activated Inhibitory Factor 1Waif1 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Trophoblast Glycoprotein5t4 Oncofetal Antigen protein5t4 Oncofetal Trophoblast Glycoprotein5t4 Oncotrophoblast GlycoproteinM6p1 proteinWnt-Activated Inhibitory Factor 1 proteinWaif1 proteinTPBG protein5T4 protein |
Information sourced from Uniprot.org