Human VTCN1/B7-H4 protein (Recombinant-Active) (C-His) (STJP012182)

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STJP012182-100
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Human VTCN1/B7-H4-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: VTCN1
Gene ID: 79679
Uniprot ID: VTCN1_HUMAN
Immunogen Region: Phe29-Ala258
Immunogen: Homo sapiens (Human)
Post Translational Modifications N-glycosylated.
Function Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
Protein Name V-Set Domain-Containing T-Cell Activation Inhibitor 1
B7 Homolog 4
B7-H4
B7h.5
Immune Costimulatory Protein B7-H4
Protein B7s1
T-Cell Costimulatory Molecule B7x
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Expressed At The Cell Surface
A Soluble Form Has Also Been Detected
Alternative Protein Names V-Set Domain-Containing T-Cell Activation Inhibitor 1 protein
B7 Homolog 4 protein
B7-H4 protein
B7h.5 protein
Immune Costimulatory Protein B7-H4 protein
Protein B7s1 protein
T-Cell Costimulatory Molecule B7x protein
VTCN1 protein
B7H4 protein
UNQ659 protein
PRO1291 protein

Information sourced from Uniprot.org

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