| Function | Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their ATP-dependent disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan. (Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). |
| Protein Name | Vacuolar Protein Sorting-Associated Protein 4bCell Migration-Inducing Gene 1 ProteinSuppressor Of K(+ Transport Growth Defect 1Protein Skd1 |
| Database Links | Reactome: R-HSA-162588Reactome: R-HSA-917729 |
| Cellular Localisation | Late Endosome MembranePeripheral Membrane ProteinMembrane-Associated In The Prevacuolar Endosomal CompartmentLocalized In Hiv-1 Particles Purified From Acutely Infected Cells |
| Alternative Protein Names | Vacuolar Protein Sorting-Associated Protein 4b proteinCell Migration-Inducing Gene 1 Protein proteinSuppressor Of K(+ Transport Growth Defect 1 proteinProtein Skd1 proteinVPS4B proteinSKD1 proteinVPS42 proteinMIG1 protein |
Information sourced from Uniprot.org
