Human VEGFC protein (Recombinant-Active) (C-His) (STJP012604)

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STJP012604-100
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Short Description :Recombinant-Active-Human VEGFC-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Applications:ELISA/WB
Host:Mammalian Cells
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Dilution Range:Reconstitute in sterile water for a stock solution.
Formulation:Lyophilized from a 0.22 Mu m filtered solution in 20mM PB, 150mM NaCl, 0.05% Tween 80, pH 8.0.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:< 1 EU/µg as determined by LAL test.
Gene Symbol:VEGFC
Gene ID:7424
Uniprot ID:VEGFC_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Phe32-Arg227
Post Translational Modifications Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing a heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.
Function Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors.
Protein Name Vascular Endothelial Growth Factor C
Vegf-C
Flt4 Ligand
Flt4-L
Vascular Endothelial Growth Factor-Related Protein
Vrp
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-194313
Reactome: R-HSA-195399
Cellular Localisation Secreted
Alternative Protein Names Vascular Endothelial Growth Factor C protein
Vegf-C protein
Flt4 Ligand protein
Flt4-L protein
Vascular Endothelial Growth Factor-Related Protein protein
Vrp protein
VEGFC protein

Information sourced from Uniprot.org

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